Determination of neutron relative biological effectiveness factors for BNCT and test of different boron compounds (Long Term Proposal)
The measurements proposed in this project pursue the advance in two key research lines for improving Boron neutron capture therapy (BNCT): one is the accurate calculation of the photon equivalent dose in BNCT which is essential for the treatment planning and the second is the search of better boron compounds for the therapy. In the first problem we want to improve the data on the relative biological effectiveness factors for the main dose contributions: thermal, gamma from H capture and boron dose. The PF1b line at ILL is unique for these measurements due to the high flux and the lack of gamma contamination in the beam. The second one is the study of compounds that can potentially deliver much more boron atoms to the tumor cells, which would represent a major advance for the therapeutic capability. For this purpose boron-loaded nanostructures are specially promising because they can carry a lot of boron atoms to the tumors via the enhanced permeation and retention effect. We will study different nanoparticles recently synthesized by the groups of Grenoble and Granada by irradiation of the cells previously treated with these compounds and observing the joint effect.
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I. Porras; ARIAS DE SAAVEDRA Fernando; AUZELY VELTY Rachel; BUSSER; CHAPEROT Laurence; COLL Jean Luc; DOSDA Emilien; FORSYTH Victor Trevor; KOESTER Ulli; PATRONIS Nikolaos; PEDROSA Maria; J. Praena; ROUSSET xavier; RUIZ Carmen; MJ Ruiz-Magaņa; M.P.Sabariego; SANCEY Lucie and SOLDNER Torsten. (2018). Determination of neutron relative biological effectiveness factors for BNCT and test of different boron compounds (Long Term Proposal). Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.3-07-381
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