Mapping complex hydrogen-bonded networks in quinoline-based antimalarial drugs
This proposal is devoted to the structural and crystallographic investigation of the hydrogen bond (HB) network in high-quality single crystals of the antimalarial drug chloroquine by single-crystal neutron diffraction at low T (down to 100 K). This experiment will complement high-resolution X-ray diffraction results, allowing to clarify the role of hydrogen bonds in setting up the molecular recognition process.
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LO PRESTI Leonardo; LEMEE Marie Helene; LOCONTE Laura; MACETTI Giovanni; MOSSOU Estelle; RIZZATO Silvia; SILVESTRINI lucia and SOAVE Raffaella. (2015). Mapping complex hydrogen-bonded networks in quinoline-based antimalarial drugs. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.5-12-319
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