Investigations of amorphous pharmaceutical materials obtained from different routes
The development of pharmaceutical substances in the amorphous state has recently motivated a strong interest since this disordered state shows highest solubility properties than the crystalline state in which the pharmaceuticals are usually prepared. This amorphous state can be obtained from different routes: classical melt-quench, grinding, freeze-drying,... The characterization and comparison of amorphous materials made by those different approaches is particularly challenging since many open questions remain on the nature of the amorphous forms. The main scope of this proposal will be to investigate the microstructural organization of molecular materials of pharmaceutical interests obtained from different routes using a D3 investigation. Only a few studies have been done using this type of tools. Very significant progresses could be achieved using the possibilities offered by the use of large scale facilities instruments such as available at ILL.
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NGONO MEBENGA Frederic; AFFOUARD Frederic; CUELLO Gabriel; JIMENEZ RUIZ Monica; STUNAULT Anne and WILLART Jean Francois. (2015). Investigations of amorphous pharmaceutical materials obtained from different routes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.6-05-967
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