Understanding the grafting of fluorophore molecules on Carbon Nanotubes: aprerequisite for toxicity studies
The extraordinary physical properties and their 1D morphology of carbon nanotubes (CNTs) has quickly led to many applications in various fields including biology (drug-delivery, scaffolds, imaging, sensors). Use of CNTs always requires their dispersion (de-agglomeration, individualization), obtained by functionalisation, covalent or not (simple adsorption). For covalent grafting, the question of the competition between real grafting and simple adsorption is very relevant and has never been investigated rigorously. This is however a central question, and especially in the field of nanotoxicology and biomedical applications of CNTs: they are for ex. generally tracked inside biological matrices by functionalisation with fluorophores (fluorescence being associated to CNTs). However, fundamental questions are raised as there is no simple evidence that a fluorophore adsorbed on a CNT will stay there forever once inside a cell (molecules with a stronger affinity could lead to desorption of the fluorophore), leading to wrong conclusions. The project aims at using neutrons to identify adsorption sites on CNTs and investigate the ratio between covalent and non-covalent interactions.
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LORNE Thomas; FLAHAUT Emmanuel; JIMENEZ RUIZ Monica and ROLS Stephane. (2015). Understanding the grafting of fluorophore molecules on Carbon Nanotubes: aprerequisite for toxicity studies. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.7-05-455
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