Biomimetic models of the outer membrane of Gram-negative bacteria and their interaction with two complementary antimicrobial peptides.
Resurgence of bacterial resistance to antibiotics has become a major public health issue. Antimicrobial peptides are very promising molecules for the development of new anti-infective therapies. However, their mechanisms of action on bacterial membranes are still poorly understood. My project aims to develop innovative models of membranes, imitating both the structure and the composition of the membranes of Gram-negative bacteria, and allowing the screening of potentially active antimicrobial peptides and the elucidation of their mechanism of action. Two new antimicrobial peptides belonging to the family of plasticins, one active and the other inactive, will be used as model drugs. Their interaction with pure symmetric PL/PL and asymmetrical LPS/PL floating and adsorbed bilayers will be studied by neutron reflectommetry in order to examine both the physical state and the symmetrical/asymmetrical organization of the membrane, as well as the influence of concentration and aggregation state of plasticins penetrating into it.
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
MICHEL Jean Philippe; FRAGNETO Giovanna; GERELLI YURI; GUTFREUND Philipp and ROSILIO Veronique. (2013). Biomimetic models of the outer membrane of Gram-negative bacteria and their interaction with two complementary antimicrobial peptides.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-669
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.