Neutron reflectivity studies of the interaction between human antimicrobial peptides and gram negative membrane models
Lipopolysaccharide (LPS) molecules released from the outer membrane (OM) of infecting Gram negative bacteria induce an uncontrolled inflammatory response in humans which can lead to severe septic shock. LPS molecules also act as the bacterium’s permeability barrier making it therefore less susceptible towards external agents and drugs. Human antimicrobial peptides (hAMPs) of diverse 3D structure have the capacity to disrupt the bacterial cell membrane. The mechanism of action for this phenomenon is not fully understood yet and might be affected by different chemotypes of LPS; hence further studies need to be performed in order to gain deeper insight into this interaction. Neutron reflectivity studies at the air/water interface will help to clarify these interactions between human antimicrobial peptides and outer membrane models.
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BELLO Gianluca; BARKER Robert; BODIN alice and Richard D. Harvey. (2013). Neutron reflectivity studies of the interaction between human antimicrobial peptides and gram negative membrane models. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-672
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