Elucidating the interaction mechanism of novel antimicrobial dendrimer on reconstituted bacterial cell membranes vs. mamma-lian cell mimics
Antibiotic multiresistance is an ever-increasing problem, which has to be addressed with novel approaches, if this already serious public health issue is to be contained. The prospect of exploiting dendritic structures as scaffolds for antimicrobial peptide (AMP) based agents with increased activity have led to synthesis of novel AMP dendrimers. We have already extensively studied a dendrimer of this type and these studies revealed a significant interaction with fluid membranes. They showed that the dendrimers were able to penetrate the lipid bilayer and form lipid-dendrimer micellar-like complexes, which resulted in solubilisation of the mammalian model membrane. The dendrimer (BAIN) selected for the present studies has shown high activity towards bacteria of different genera including even resistant laboratory strains. Furthermore and of paramount importance, this compound is non-toxic to human cells. We wish to study the interaction between dendrimer BAIN and supported lipid membranes of mammalian and bacterial lipids in order to clarify this selectivity. The outcome of this project will be of major relevance in the on-going optimization of the design of effective antibiotics.
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WACKLIN KNECHT Hanna; BARKER Robert; CARDENAS; DARRE Leonardo; Tania Kjellerup Lind; URBANCZYK-LIPKOWSKA Zofia and ZIELNISKA Paulina. (2013). Elucidating the interaction mechanism of novel antimicrobial dendrimer on reconstituted bacterial cell membranes vs. mamma-lian cell mimics. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-681
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