Mechanism of cell membrane disruption by IAPP
IAPP is an amyloid peptide which causes diabetes by killing beta-pancreatic cells. However, the mechanism and kinetics of cell destruction remain under debate. Here, we intend to study the disruption of model liposome systems by different fragments of this peptide in order to map the IAPP sequence for cytotoxicity and to detect, by correlation with structural data, which oligomeric intermediates of fiber formation are cytotoxic. The results of this time-resolved functional study, together with already available structural and functional data will improve our global understanding of IAPP amyloid aggregation and cytotoxicity. A precise understanding of the aggregation process including the description of each intermediate species, their energetic and cytotoxic effect could have tremendous implication in the development of therapeutics against amyloid diseases.
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MARTEL Anne and PORCAR Lionel. (2013). Mechanism of cell membrane disruption by IAPP. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-688
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