Role of omega-3 fatty lipids on the interaction of Alzheimer's Ab peptide with lipid bilayers.
Polyunsaturated omega-3 fatty acids are increasingly proposed as dietary supplements able to reduce the risk of development or progression of the Alzheimer’s disease (AD). AD is characterized by cognitive impairment, intracellular neurofibrillary tangles, synaptic loss, and extracellular amyloid plaques. Many evidences have suggested a direct implication of lipid membranes in the mechanisms of fibrillization, favoring the Ab misfolding and aggregation. The 22:6(cis)PC is the most abundant polyunsaturated acyl chain present in the phospholipid constituting mammalian brain. Some studies suggest that fatty acids may delay or prevent the progression of AD. To date, the molecular mechanism through which these lipids act has not been yet univocally identified. In this contest, we plan to study on the effect of the 22:6(cis)PC presence in lipid bilayers mimicking the natural membrane by means of NR measurements. The aim of our research is to investigate the influence of the omega-3 lipid, 22:6(cis)PC, on the biophysical properties of lipid bilayers, and on their interaction with the amyloid peptide fragment Aβ(25−35).The role of cholesterol and sphyngomyelin presence will be also studied.
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VITIELLO Giuseppe; FRAGNETO Giovanna; LUCHINI Alessandra and PADUANO Luigi. (2014). Role of omega-3 fatty lipids on the interaction of Alzheimer's Ab peptide with lipid bilayers.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-703
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