How do neutrons see phosphatidyl serine? Ca-bound and Ca-free forms of PS studied by neutron reflectometry at the air-water interface.
Phosphatidyl serine (PS) is a phospholipid that is crucially important in blood clotting and cell membrane repair. It has a strong affinity for Ca2+ and serves as a binding site for a variety of proteins (e.g., clotting factors, annexins), both in the Ca-free and Ca-dependent manner. While it has been extensively studied by a variety of spectroscopic methods and extensively used in various membrane model systems to investigate cell membrane behavior and lipid-protein interactions, precious little work has been done by neutron reflectometry (NR) to characterize this lipid. Crucial physico-chemical parameters of Ca-bound PS headgroup are not known, and questions about its interactions with other lipids remain. NR experiments at the air-water interface proposed here are aimed at characterizing PS headgroup in the Ca-bound and Ca-free form to fill that gap in our knowledge.
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REVIAKINE Ilya and BARKER Robert. (2015). How do neutrons see phosphatidyl serine? Ca-bound and Ca-free forms of PS studied by neutron reflectometry at the air-water interface.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-708
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