Biomimetic bilayers mimicking the outer membrane of Gram-negative bacteria and their interaction with antimicrobial peptides
We plan to prepare model membrane systems of the outer membrane of Gram negative bacteria and study the mechanisms regulating the penetration of antimicrobial peptides into the asymmetric outer membrane. Asymmetric phospholipids/lipopolysaccharide bilayers will be formed by Langmuir-Blodgett techniques to mimic the outer membrane of Gram-negative bacteria cell wall.The structural modifications of the bilayer due to interaction with selected antimicrobial peptides will be monitored with increasing peptide concentrations as well as different H2O/D2O media to allow a better accuracy in data analysis. These results combined with our QCM-D and x-ray diffraction measurements will constitute a body of evidence of the penetration mechanism of plasticins into the asymmetric outer membrane.
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MICHEL Jean Philippe; FRAGNETO Giovanna; GERELLI YURI and ROSILIO Veronique. (2015). Biomimetic bilayers mimicking the outer membrane of Gram-negative bacteria and their interaction with antimicrobial peptides. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-718
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