Investigating tethered lipid bilayer biosensor platforms: structure/function relationships
We propose to perform combined measurement of neutron reflectometry (NR) and impedance spectroscopy (IS) to determine the structure function/relationship of tethered lipid bilayer biosensor platforms built up by tethered bilayer systems with embedded membrane transport proteins. The interpretation and modeling of IS data are related to structural detailed of the membranes. These can be obtained by modeling NR data to improve/constraint IS data, and vice versa. Hence, IS in situ monitoring of the biomimetic membrane activity during NR experiments would boost the ability of a full characterization of the biomimetic membrane obtained singularly with each of the two techniques. We will apply this combined NR/IS measurement to obtain a characterize lipid bilayer systems tethered to gold substrates, with proteins membrane proteins like OprF or VDAC.
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MACCARINI Marco; ALCARAZ Jean Pierre; FRAGNETO Giovanna; GAYET Landry; KOEHLER Sebastian; MARTIN Donald and WATKINS Erik. (2017). Investigating tethered lipid bilayer biosensor platforms: structure/function relationships. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-748
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