The interaction between amyloid beta peptides and model membrane containing cholesterol and/or melatonin
Alzheimer`s disease (AD) is a devastating neurodegenerative disease caused by the formation of senile plaques, primarily consisting of amyloid-beta (Ab) peptides. The crucial role in this process is imparted by peptide-membrane interactions, changing the structural properties of membrane. These changes are known to be modulated also by membrane composition. In particular, cholesterol increases the order of lipid hydrocarbon chains and increases the stiffness of membrane. On the other hand, melatonin increases the fluidity of membrane. Our previous experiments [Drolle et al., BBA 2013] revealed the counteracting effect of melatonin to that of cholesterol. We propose to investigate model membranes loaded with transmembrane Ab peptide with the addition of cholesterol, melatonin, and cholesterol and melatonin. We expect the bilayer structure to reflect the elevated amounts of cholesterol by its thickening, while the fluidizing effect of melatonin should evoke the membrane thinning. Results of this experiment may shed more light on the melatonin's potential role in preventing the development of AD.
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KONDELA Tomas; DEME Bruno and KUCERKA Norbert. (2016). The interaction between amyloid beta peptides and model membrane containing cholesterol and/or melatonin. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-758
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