Neutron Diffraction Study of POPE Spray Coating under High Hydrostatic Pressure
Permanent metal implants are widely used and successfully implemented in medicine to address problems related to the musculoskeletal system. However, implants that interact in all cases optimally and durably with bone tissue have yet to be developed. To obtain biological active materials that provide biological cues for tissue regeneration, various coatings are applied. One of the best candidates for the implant modification is POPE lipid (phospholipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine). The polar group of this lipid has been found in some nervous tissue, such as the white matter of the brain, nerves, neural tissue, and in the spinal cord. Besides, POPE coating has proved to be a positive factor for cell-implant interactions. However, it is extremely important to verify the resilience of the coating to mechanical damage.In order to fill this gap, the main goal of this project is to perform a structural study of POPE spray coating under high pressure, which mimics the mechanical stress in knees etc. The properties of POPE coating under high hydrostatic pressure is the key parameter for further applications on real implant materials.
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GOLUB Maksym; ALTIERI Maricarmen; CAVITOLO Martina; CRISTIGLIO Viviana; DE LUCA Oreste; DEME Bruno; PETERS Judith; POTENZA lucia francesca and TAMMARO Olimpia. (2016). Neutron Diffraction Study of POPE Spray Coating under High Hydrostatic Pressure. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-761
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