The antimicrobial action and the synergistic interaction of two cationic linear peptides on oriented lipid bilayers
We propose to investigate the mechanism of antimicrobial action of two different cationic linear peptides, magainin 2 and PGLa, embedded in oriented lipid bilayers formed by DMPE/DMPG phospholipids. The peptides strongly influence each other in the membrane by communicating through the lipid matrix. Thus their antimicrobial and membrane activities are an order of magnitude enhanced when added in combination. In a recent study, we were able to show that a model proposed by Bicout and Zaccai (D. Bicout and G. Zaccai, Biophys. J. 80, 2001, 1115 - 1123) permitted to fit the mean square displacements extracted from elastic incoherent neutron scattering data and to obtain thermodynamic parameters such as enthalpy and entropy. We expect that the internal dynamics and thermodynamics of the lipid bilayer are strongly influenced by the presence of the peptides inside the membrane as recently presented by Barrett et al. (M.A. Barrett et al., Soft Matter 12, 2016, 1444 - 1451) and thus we would like to correlate the corresponding quantities with the functional mechanisms of the membrane-embedded peptides and their synergistic activity.
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BECHINGER Burkhard; CISSE Aline; MARQUETTE Arnaud and PETERS Judith. (2018). The antimicrobial action and the synergistic interaction of two cationic linear peptides on oriented lipid bilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-817
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