Location of membrane-active drugs in the lipid bilayer
The activity of many drugs is based on their interaction with lipid bilayers. In this proposal, we envisage to determine how deep such membrane-active drugs penetrate into the membrane in three examples: 1) the helical antimicrobial peptides PGLa and magainin-2, 2) the beta-strand antimicrobial peptide KIGAKI, and 3) the sterol squalamine which prevents amyloid formation in Parkinson disease. Using neutron small angle scattering on oriented bilayer samples, we plan to localize the compounds within the bilayer in order to get clues on their mode of action.
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GRAGE Stephan and DEME Bruno. (2018). Location of membrane-active drugs in the lipid bilayer. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-827
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