Interaction of HIV-1 p6 protein with raft mime membranes by neutron reflectometry
The 52 amino acid HIV-1 p6 protein is synthesized as the C-terminal part of the group specific antigen Gag polyprotein Pr55. In this context p6 is known to promote virus release, but during HIV-1 life cycle it is cleaved from Gag polyprotein and its function in this mature form has not been investigated yet. Recently HIV-1 p6 has been found to interact with plasma membrane and eventually to form pores. Aim of this proposal is to study the interaction of the small p6 protein with model membranes to investigate the structural changes induced by the interaction of this small soluble protein on model membranes as a function of membrane composition, from phospholipid bilayers to more complex biomimetic membranes (raft-mime).
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DEL FAVERO Elena; BROCCA Paola; CANTU Laura; DI COLA Emanuela; FRAGNETO Giovanna; GRAVA Miriam and RONDELLI Valeria Maria. (2019). Interaction of HIV-1 p6 protein with raft mime membranes by neutron reflectometry. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-849
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