Curvature-induced lipid segregation studied by grazing incidence neutron scattering on nanoparticle-supported lipid bilayers (NP-SLB)
Biological membrane in plane organisation is a challenging topic, specially since it has been suggested to depend on curvature. So far the main approach to study curvature-induced in plane phase separation has been through the approach of fluorescent techniques and liposomes. Here we propose to use grazing incidence neutron scattering to explore the signal from a well ordered nanoparticle coated surface and use it as a solid substrate to form curved supported lipid bilayers by vesicle fusion. The curvature of the membranes will be tuned by the size of the nanoparticles in the surface coating and specular and off-specular reflectivity will be used to probe the in-in plane lipid organisation and the SLD distribution normal to the surface.
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Nicoḷ Paracini; CARDENAS; Yubexi Correa; Christopher J. Garvey; GUTFREUND Philipp; Armando Maestro and WOLFF Maximilian. (2020). Curvature-induced lipid segregation studied by grazing incidence neutron scattering on nanoparticle-supported lipid bilayers (NP-SLB). Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-889
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