Going deeper in the structural characterization of pulmonary surfactant films at the air-liquid interface
Covering the alveolar air-liquid interface, pulmonary surfactant is essential to maintain operational breathing by reducing surface tension. Pulmonary surfactant forms a highly dynamic multilamellar membrane film in the alveolar air-liquid interface. Triggered by respiratory mechanics, surfactant membranes undergo remarkable structural changes that are not well characterised yet. That is the reason why neutron reflectometry of adsorbed surfactant films in an air-liquid interface and subjected to compression-expansion cycles appears to be a promising technique to address such quantitative structural characterization. Here, we aim to understand in detail how surfactant lipids and proteins interact in such dynamic surface-active material. For this purpose, we will perform experiments on FIGARO using, not only model lipids in combination with surfactant proteins B and C, but also surfactant from biological sources that keep the native lipid-protein interactions. In such a way, we expect to be in position to attribute a structural role in surfactant homeostasis to both lipids and proteins.
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Cruz A.; Javier Carrascosa-Tejedor; CASTILLO SANCHEZ Jose Carlos; Collada, A; Armando Maestro; PEREZ-GIL Jesus and SANTAMARIA Andreas. (2021). Going deeper in the structural characterization of pulmonary surfactant films at the air-liquid interface. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-891
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