The role of charge regulation on the interaction of Histatin 5 with cell membranes
A number of salivary proteins act as the first line of defense against bacterial and fungal overgrowth. Among these, Histatin 5 (Hst5) is a salivary gland secreted cationic peptide, characterized as an intrinsically disordered protein. Hst5 is a histidine-rich, 24 amino acids protein, which activity of inhibition of growth and viability of Candida albicans has been evaluated using a variety of techniques. However, the underlying mechanism is still not very well known. The aim of this project is to understand the underlying mechanism and the effect of histidines. For this purpose five variants of histidines have been designed and the goal is to understand how the lipid environment influences the activity of the proteins, utilizing neutron and X-ray scattering in combination with computer simulations.
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Marie Skepö; ERIKSSON SKOG Amanda; FRAGNETO Giovanna and GERELLI YURI. (2021). The role of charge regulation on the interaction of Histatin 5 with cell membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-902
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