Assessing the contribution of active site accommodation of glycerophospholipid in regulating the specificity of iPLA2γ
The project is the latter part of a previously accepted proposal that attempts to define the complexities underlying how GPLs and the mitochondria-integral phospholipase iPLA2-gamma interact in a complex relationship. The proposed experiments involving the structural characterization of lipid bilayers interacting with the enzyme can give a better understanding of the principles underlying the substrate specificity of the human iPLA2-gamma by allowing us to assess the contribution of the active site accommodation of the substrate. Through the proposed measurements we will assess the contribution of unique acyl chains (as a function of degree of unsaturation) on the rate of hydrolysis by iPLA2-γ thus allowing us to shed light on the active site accommodation.
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CORUCCI Giacomo; BATCHU Krishna chaithanya; FRAGNETO Giovanna and JACOBS Robert. (2021). Assessing the contribution of active site accommodation of glycerophospholipid in regulating the specificity of iPLA2γ. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-914
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