The effect of bulkiness and charges of archaeal lipid polar headgroups on bending rigidity of archaeal membranes
The most extremophilic organisms (able to withstand extreme conditions) all belong to the Archaea. In contrast to the familiar fatty acid based lipids of bacteria and eucarya, Archaeal membranes are composed of very particular lipids, based on ether linked polyisoprenoid chains. The ether bound and the branched chains allow for a tighter compaction of the membrane, which confers increased impermeability and resistance to the harsh conditions extremophilic Archaea live in. It is known that the polar headgroup influences the bending rigidity of the lipids, but very little work has been done thus far to characterize it with precision in the example of the archaeal bilayer. In this project we want to take opportunity of newly synthesized archaeal phospholipids with different polar headgroups (serine, glycerol, inositol, choline and ethanolamine) in order to measure the impact of these polar headgroups, with varied charge and bulkiness, on the bending rigidity of a synthetic archaeal bilayer. This will give complementary information on membrane parameters with that obtained by diffraction, SAXs and NMR, and allow to fully apprehend the behavior of the membrane under extreme conditions.
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Phil Oger; DALIGAULT Camille; HOFFMANN Ingo; LORICCO Josephine and PETERS Judith. (2020). The effect of bulkiness and charges of archaeal lipid polar headgroups on bending rigidity of archaeal membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-917
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