Impact of polar headgroup moities on archaeal membrane parameters
We have proposed a novel membrane architecture to explain the stability of lipid bilayers of archaeal cells at high temperatures and pressures. In this architecture, the increase in membrane stability/rigidity is due to the presence in the midplane of the bilayer of apolar molecules. In previous experiments (8-02-762/8-02-809) using a mixture of archaeal lipids with phospho-choline and -ethanolamine headgroups, we have demonstrated that the apolar molecule is located inside the membrane. Using different approaches (FTIR, SAXS, DSC), we further demonstrated the predicted increase in stability/rigidity and impact on permeabilty. Membrane parameters depend largely on polar headgroup properties. In the current experiment, we now want to explore the differential behavior of the membrane as a function of the nature of the polar headgroup moity using 4 novel synthetic archaeal lipids made available through the ANR ArchaeoMembrane program. These lipids have chemical structures more closely related to natural lipids of Archaea. Using these lipids we will be able to evaluate the relative contribution of the polar and apolar moities on membrane physical parameters in the archaeal bilayer.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
LORICCO Josephine; Antonino Caliņ; DEME Bruno; NIDRICHE Agathe; Phil Oger and PETERS Judith. (2021). Impact of polar headgroup moities on archaeal membrane parameters. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-919
This data is not yet public
This data is not yet public
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.