Interaction of advanced drug delivery vehicles with model biomembranes
There has been a shift in the pharmaceutical industry's focus towards development of drugs that act at specific sub-cellular compartments, thereby creating a demand for advanced delivery vehicles that convey their drug payload to the required site of action. A common feature of intracellular drug delivery is that the delivery vehicle is taken up by the target cells via endocytosis with the vehicle becoming engulfed in the endosome. In order for the drug to exert its action, it must escape from the endosome. Neutron reflectometry will help to unravel the interaction(s) between polymeric nanoparticles of interest here and the endosomal membranes (and in particular the early and late stage endosomal membranes) to enable the design of efficient delivery vehicles that can escape the endosome at an early stage with an intact drug payload.
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M Jayne Lawrence; Richard A. Campbell; JACKMAN Mark; Armando Maestro; MICCIULLA Samantha; WINNALL Samuel and Marianna Yanez Arteta. (2021). Interaction of advanced drug delivery vehicles with model biomembranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-944
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