New information about the structure and dynamic composition of lipid reservoirs mediated by lung surfactant protein B at low surface tension
Neonatal respiratory distress syndrome is an acute condition suffered by premature babies who have suppressed amounts of lung surfactant protein SP-B. The protein is understood to function by nucleating lipid reservoirs at the air/water interface as the surface of the lungs is compressed during expiration, allowing surplus lipid confined close to the surface monolayer to spread rapidly and maintain very low surface tension during inhalation. Only intuitive physical pictures of the reservoirs have been proposed to date due to the extreme experimental challenge of resolving structures at fluid interfaces under physical conditions that mimic respiration. This proposal builds on lab data where we have done exactly that as phosphatidylglycerol lipids appear to modulate the squeeze out of unsaturated lipids from the surface monolayer by an SP-B analogue called Mini-B at low surface tension during multiple cycles of the surface area. Structural and compositional neutron reflectivity data are proposed to resolve unique information under dynamic cycles of the surface area at low surface tension for the first time. The work will lead to future studies on more advanced lung surfactant models.
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Richard A. Campbell; Javier Carrascosa-Tejedor; Glenn J. Coope; GUTFREUND Philipp; M Jayne Lawrence; Armando Maestro; SAERBECK Thomas and YAN Yixuan. (2021). New information about the structure and dynamic composition of lipid reservoirs mediated by lung surfactant protein B at low surface tension. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-962
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