Floating lipid bilayers stabilized by adhesion-inducing glycolipids
Glycolipids influence the behavior of lipid bilayers in various ways with consequences for the functions of biological membranes. Based on our earlier work we have identified glycolipid/phospholipid binary mixtures comprising synthetic glycolipids that either strengthen bilayer adhesion or lead to enhanced chain ordering. Here we intend to study floating lipid bilayers (FLBs) incorporating different types of glycolipids at defined lateral densities and to structurally characterize them by NR. We are going to investigate (i) how the glycolipids affect the water layer thickness and FLB stability, (ii) whether glycolipids are recruited to the inner leaflet to increase the number of favourable sugar contacts and (iii) whether or not certain glycolipids reduce the bilayer fluidity and thereby slow down the flip-flop of phospholipids within the bilayer. Moreover, we will explore to what extent glycolipid-induced adhesion on the long trerm is suited to selectively promote the fusion or bilayer formation of native biomembrane vesicles.
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SCHNECK Emanuel; BANGE Lukas; FRAGNETO Giovanna; MICCIULLA Samantha; MUKHINA Tetiana and RONDELLI Valeria Maria. (2021). Floating lipid bilayers stabilized by adhesion-inducing glycolipids. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-966
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