What's underneath? gangliosides rearrangement in cancer diseases
The two major sialic acid variants that can be found in mammals gangliosides are N-acetylneuraminic acid (Neu5Ac) and N-glycolyneuraminic acid (Neu5Gc). Normally Neu5Gc-sialoconjugates are absent from human tissues. However, expression of N-glycolylated gangliosides has been observed in a wide range of human cancers. GM3(Neu5Gc) has been considered as a tumor-specific antigen and as a target for cancer immunotherapy. Moreover, membrane glycosphingolipids regulate lateral membrane movements via cholesterol and sphingolipid-rich membrane rafts. Changes in rafts have been shown to promote proliferative signaling through lateral membrane microdomain re-organisation. Thus, the analysis of the arrangement of GM3 in lipid rafts and the observation of the differences in the behaviour of GM3Neu5Gc can be transferred in information for the development and optimization of novel therapeutic strategies based on targeting lipid rafts of cancer cell membranes.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
RICCI Caterina; DEL FAVERO Elena; FRAGNETO Giovanna; Ben Humphreys and Nicoḷ Paracini. (2023). What's underneath? gangliosides rearrangement in cancer diseases. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-977
This data is not yet public
This data is not yet public
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