Interaction of supported phospholipid membranes with protein-corona covered silica nanoparticles
Interaction of bio-membranes with inorganic nanoparticles presents great interest in relation to practical applications in nanomedicine and nanotoxicology. Motivated by a previous Neutron Spin Echo study (Hoffmann et al. Nanoscale 2014, 6, 6945) where the surprising finding of phospholipid membrane softening (reduction of bending rigidity) under the binding of silica nanoparticles (SiNP) was reported, we have performed a series of experiments and molecular dynamics simulations, aiming at the elucidation of the structural aspects of the interaction between SiNP and supported phospholipid membranes. Our results indicate that local membrane disorder due to SiNP attachment is related to the observed dynamic behavior. Our intension with this proposal is to further exploit the power of the multiple solvent-contrast neutron reflectivity technique and to extend our investigation in the case of SiNP coated by a protein corona, that represents a scenario of high biological relevance.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
Alexandros Koutsioubas; Nicoḷ Paracini and Andreas M. Stadler. (2023). Interaction of supported phospholipid membranes with protein-corona covered silica nanoparticles. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-979
This data is not yet public
This data is not yet public
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