NR determination of structural changes of myelin membranes by application of electrical potential gradients
Myelin is an asymmetric multilamellar membrane wrapped around the axons and consists of alternating extracellular and cytoplasmic leaflets. Any structural changes of the myelin sheath, mainly demyelination, are signatures of several inflammatory neurological disorders as Multiple Sclerosis (MS). We suggest generating flat asymmetric myelin membranes with intercalated MBP, which are suitable for Neutron Reflectometry (NR) analysis. We aim to obtain a precise measurement of the vertical membrane layer structure for native myelin. We also plan to analyze the structural changes of myelin membranes by application of electrical potential gradients which emulate neuronal action potentials.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
Julio M. Pusterla; Alexandros Koutsioubas; Nicoḷ Paracini and Andreas M. Stadler. (2023). NR determination of structural changes of myelin membranes by application of electrical potential gradients. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-993
This data is not yet public
This data is not yet public
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.