Solution structure of mTSPO membrane protein in biomimetic systems
We focus on mouse TSPO (mTSPO), a ubiquitous and functionally important translocator membrane protein, used as a marker in many brain and cancerous diseases in human. Recently, we determined, using SANS and ab initio modeling, the low resolution structure of mTSPO without ligand in SDS (the detergent used to extract and purify the protein) and in DPC (used to solve mTSPO structure by NMR, but in the presence of a stabilizing ligand). We intend now to characterize the solution structure of mTSPO, with and without ligand, in different biomimetic membrane environments: lipid/detergent mixtures and lipid nanodiscs.
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The recommended format for citing this dataset in a research publication is in the following format:
COMBET Sophie; finet; MARTEL Anne; POZZA Alexandre and SAADE Christelle. (2023). Solution structure of mTSPO membrane protein in biomimetic systems. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-1069
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This data is not yet public
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