SANS investigations on aggregation phenomena in supersaturated drug solutions
Non-ionic Iodinated Contrast Media (NICM) are investigative drugs of great relevance in delicate radiological analysis like angiography. The success of these molecules mainly resides in some peculiar physic-chemical properties that associate relatively low-osmolality with low-viscosity up to high concentration in water. NICM are characterized by atropisomerism, a particular chirality due to hindered rotations that gives rise to metastable conformational isomers in solution. The hypothesis is that atropisomeric conformational disorder is stabilized in the molecular aggregation, a phenomenon that inhibits crystallization from supersaturated solutions [5]. Since atropisomers can in principle be equilibrated thermally and NICM solutions are supersaturated, two key factors are identified in temperature and concentration. We propose to use the D11 diffractometer to investigate as a function of temperature and concentration the behavior of atropisomeric drug molecules in solution that allows stability of supersaturated solutions.
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TAVAGNACCO Letizia; BELLICH Barbara; BRADY J.W.; CESARO Attilio; GERELLI YURI and SCHWEINS Ralf. (2015). SANS investigations on aggregation phenomena in supersaturated drug solutions. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-809
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