Sructural Study of Functional Nucelosome with Human Varinat Histones
Nucleosome, which consists of histone octamer and DNA, is a fundamental unit for stable storage of genomic DNA. In an activation stage, such as transcription, recombination, repair, and replication, the nucleosome has to diverge from its stable structure: for example, on the active genes, genomic DNA must detach from the histone core to allow access of the transcription factors. It is expected that the trigger of the activation could be replacement of histones by the variant histones, accompanying with the structural alternation. Recently, we have focused on the variant nucleosome with H2A.Z histone, which is predominantly localized around the promoters of active genes. In this project, we will elucidate the configuration of DNA and structural modulation of histone octamer in H2A.Z nucleosome using small-angle neutron scattering with contrast variation technique.
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Masaaki Sugiyama; HORIKOSHI Naoki; INOUE Rintaro; MARTEL Anne; PORCAR Lionel; VIGILD Martin and ZACCAI Joseph. (2014). Sructural Study of Functional Nucelosome with Human Varinat Histones. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-824
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