Interaction of Hyaluronan and Phospholipids
We propose an experiment to study the interaction of hyaluronan (HA) with the two phospholipids DPPC and DPPE. A deeper understanding of the interaction between lipids and HA will improve the knowledge about the reasons for the outstanding lubrication in joints. For our experiment, we will use unilamellar vesicles as a model system which mimics the bilayer self-assembly. Interesting is the question if HA influences vesicle properties like the bilayer structure and phase behaviour and how the structure of HA is influenced by the lipids. To obtain this information the possibilities of contrast variation will be needed. This experiment will be performed in the frame of the Röntgen-Angstrom-Cluster BMBF “Verbundprojekt 05K2012: JOINT”.
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ZANDER Thomas; HARAMUS Vasyl; PORCAR Lionel and WIELAND Dietmar. (2014). Interaction of Hyaluronan and Phospholipids. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-828
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