Density profile of DNA packaged in Herpes Simplex Virus type 1 revealed by contrast variation SANS
In human Herpesviruses, the viral genome is a double-stranded DNA molecule which is several hundred times longer than the diameter of the capsid. This physical situation leads to genome bending stress and strong repulsive interactions resulting in internal capsid pressures reaching 20 atm. The energy and the structure of the confined viral genome are the two physical parameters that control genome ejection and packaging. Using contrast variation SANS we aim to provide a description of the viral genome packaging density in the capsid which in turn is correlated with its energy. Our unique approach uses measurements on viruses in liquid, which will allow us to apply the solution conditions mimicking the cellular environment.
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Alex Evilevitch; FREEMAN Krista; OLSSON Ulf; SCHWEINS Ralf and Andrea Scotti. (2016). Density profile of DNA packaged in Herpes Simplex Virus type 1 revealed by contrast variation SANS. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-889
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