Exosomes: structural characterization and interaction with gold nanoparticles
Exosomes are cell secreted vesicles involved in cell signaling, trafficking and, in general, intercellular communication phenomena. In this view, they are of great interest as biological targets for therapeutics and diagnostics. Moreover, they can be useful platforms for biophysical studies on cell-related phenomena, bridging the complexity of cells and the simplicity of synthetic cell membrane model systems. However, despite these extremely promising features, fundamental studies on exosomes are still lacking. After a pilot experiment where we were able to measure a SANS spectrum on a prototypical exosomal sample, we plan to use SANS to obtain a structural characterization of exosomes and of their interaction with nanosystems.
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MACCARINI Marco; BERGESE Paolo; BERTI Debora; MONTIS Costanza; SCHWEINS Ralf; Valle Francesco and ZENDRINI Andrea. (2016). Exosomes: structural characterization and interaction with gold nanoparticles. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-892
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