Testing the role of exosomes in the spread of neurodegenerative deseases
Exosomes are nanosized extracellular lipid vesicles secreted by cells and circulating in biological fluids used for long-distance intercellular communication by transporting and delivering different type of biological cargoes. Exosomes might have a role in the Alzhaimer diseases (AD), since the propagation of AD through the brain could be linked to exosome transport of beta-amyloid peptides (Ab) and more importantly of its precursors protein (APP). We found that neural exosomes bind to other neurons with a certain degree of specificity, in particular APP enriched exosomes target only neurons in contrast with those not enriched with APP. Thus, it appears that APP and its pathogenic fragments have the ability to hijack a specific population of exosomes and thereby acquire specificity to target brain neurons. If confirmed, this could elucidate possible mechanisms of spreading of Ab throughout the brain, and could pave novel ways towards curing of AD. With this proposal we want to study nanostructural details of the two kinds of exosomes, and assess their properties as colloidal system by probing their interaction with model lipid membrane mimicking those of neurons and glia
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MACCARINI Marco; ALCARAZ Jean Pierre; CHATELLARD christine; LAULAGNIER; MARTIN Donald; SADOUL Rémy and SCHWEINS Ralf. (2017). Testing the role of exosomes in the spread of neurodegenerative deseases. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-895
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