Structural conformation of ApoE3 and ApoE4 in reconstituted HDL particles mapped by SANS and contrast variation
In atherosclerosis lipids and fibrous elements accumulate in the blood vessels forming plaque that leads to the hardening of arteries and eventually to heart disease and stroke. This is the leading cause of death in the west and mortality rates double that of cancer. Different lipoprotein particles have been shown to play a role in the development and the progression of atherosclerosis and are currently used as biological markers, in addition to measurements of total lipid and cholesterol in the serum. Yet many people still develop the disease even when their blood lipid values fall within the healthy range. Better standards and methods for diagnostics of atherosclerosis are necessary for its prevention while a more comprehensive understanding of the mechanism of action behind the lipoprotein particles is crucial for the development of targeted therapies in the fight against cardiovascular disease. In this project, we are under way to understanding the lipid exchange dynamics and structure relationship for different lipoproteins to better understand initial plaque build-up at the onset of atherosclerosis
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CARDENAS; FORSYTH Victor Trevor; HAERTLEIN Michael; MARIC Selma; MOULIN Martine; PREVOST Sylvain and Sarah Waldie. (2018). Structural conformation of ApoE3 and ApoE4 in reconstituted HDL particles mapped by SANS and contrast variation. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-912
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