Investigation on monomer exchange and synchronization on Kai circadian clock system
Biological clock, consisting of many biomolecular oscillators, has been attracted by researches from Biology to Mathematical physics because the clock mechanism is related with wide range of sciences. For example, there are three significant questions about biological clock: the oscillation mechanism, the synchronization mechanism between all oscillators and the temperature compensation mechanism. The circadian oscillator in cyanobacteria is the best system of choice for this research because its oscillator consists only of three proteins, KaiA, KaiB and KaiC, which display ATP-dependent complex-formation and dissociation with a 24-hour period. In the last few decades, the oscillation mechanism is being clarified. Therefore, we are focusing on the synchronization mechanism. Non-linear dynamics points out that there should be a weak interaction which works between oscillators at one phase point. We supposed that the weak interaction should be monomer exchange between the KaiC hexamers and succeeded to prove that the monomer exchange does exist. In this proposal, we will reveal the monomer exchange in detail and its relation with clock phase with deuteration-labelling SANS method.
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Masaaki Sugiyama; MARTEL Anne; Ken Morishima; PORCAR Lionel; YAGI Hirokazu; YUNOKI YASUHIRO and ZACCAI Joseph. (2018). Investigation on monomer exchange and synchronization on Kai circadian clock system. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-924
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