What is the effect of lipid exchange on the structure of artificial HDL made from ApoE?
Atherosclerosis, the main killer of the West, is directly associated to the plasma levels of low and high-density lipoproteins (LDL and HDL, respectively). These particles have been traditionally considered as bad and good cholesterol, as they either deposit or remove lipids from the vessel wall, respectively. The consequences of this lipid deposition in the artery walls include fat plaque build-up leading to cardiovascular diseases such as heart attacks and strokes. Fundamental information regarding the lipid exchange kinetics and the role played by the specific apolipoprotein present in the particles is missing. Understanding and determining the importance of the lipoprotein particle composition is fundamental in the diagnosis and treatment of the disease. The goal of this project is to understand the influences on the development of atherosclerosis by following the interaction and exchange of lipids with reconstituted lipoprotein particles and model membranes.
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Sarah Waldie; CARDENAS; FORSYTH Victor Trevor; GERELLI YURI; HAERTLEIN Michael; Dainius Jakubauskas; MARIC Selma; MOULIN Martine; Nicoḷ Paracini and PREVOST Sylvain. (2018). What is the effect of lipid exchange on the structure of artificial HDL made from ApoE?. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-942
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