Revealing radial distribution of DNA density packaged in the Herpes Simplex type 1 virus.
The icosahedral protein capsid of Herpes Simplex virus type 1 contains the tightly packed viral DNA. During the Herpes infection the DNA is ejected inside the nucleus of the host cell where it starts the virus replication (lytic infection) or is integrated in the cell nucleus and remain there indefinitely but does not replicate (latent infection). Our latest research suggest that there is a direct link between the structure of the encapsidated DNA, the dynamics of ejection and the fate of the infection, this is, whether the infection will be lytic and latent. External factors, like temperature or ionic strength in the solution, can affect the structure of the DNA and therefore the latent/lytic switch. We want to study the structure of the encapsidated DNA under different conditions as controlling the switch between lytic and latent infections is a way to stop the virus from spreading.
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Alex Evilevitch; Adrian Gonzalez; SCHWEINS Ralf; TSIMTSIRAKIS Efthymios and VILLANUEVA-VALENCIA Jose Ramon. (2021). Revealing radial distribution of DNA density packaged in the Herpes Simplex type 1 virus.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-965
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