Real time studies of the formation of ApoE-based reconstituted High Density Lipoprotein-mimics
In westernised societies, atherosclerosis constitutes the leading cause of death. The development of this disease is directly related to the concentration of high and low-density lipoproteins (HDL and LDL, respectively) in the blood. These particles remove and deposit lipids from and into the artery walls leading to plaques of fat building up and the progression to cardiovascular diseases such as heart attacks and strokes. Essential information regarding the kinetics of lipid exchange and the role played by the apolipoprotein isoform present in the particles is missing – the understanding of which could play a huge role in developing treatment for this disease. The aim of this study is to better understand the formation of the reconstituted HDL particles and the roles the apolipoproteins isoform play in relation to the lipid phase it is interacting with.
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Sarah Waldie; CARDENAS; Yubexi Correa; FORSYTH Victor Trevor; HAERTLEIN Michael; Dainius Jakubauskas; MARIC Selma; MOULIN Martine and PREVOST Sylvain. (2020). Real time studies of the formation of ApoE-based reconstituted High Density Lipoprotein-mimics. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-979
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