Photoinduced structural changes in DNA G-quadruplex-porphyrin complexes
G-quadruplex (G4) are higher-order four-stranded structures occurring in nucleic acid sequences composed of several runs of guanine nucleosides. They consist of stacks of planar G-quartets stabilized by Hoogsteen-type H-bonds. Stable G4 may inhibit telomerase extension, and are emerging as therapeutic targets for small-molecules. In this context, photosensitive ligands are a versatile platform to study how the conformation of the G4-complex can be modulated by suitable light-induced stimuli. Here we propose to use SANS to study structural modifications of G4-porphyrin complexes in both dark and illuminated states. The final goal is to define a protocol for controlling the G4 stability and conformation by a rational use of light-sensitive molecules.
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
COMEZ Lucia; COLLETIER Jacques Philippe; MARTEL Anne; Alessandro Paciaroni; SCHIRO Giorgio and WEIK Martin. (2019). Photoinduced structural changes in DNA G-quadruplex-porphyrin complexes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-980
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.