Proteome structural changes along the path toward bacterial death. A small angle neutron scattering study.
The biophysical principles at the basis of the adaptation of life to extreme environments are still elusive. Here we propose to investigate different bacteria with mesophile (Escherichia Coli) and thermophile (Thermus Thermophilus) character to understand the large-scale structural changes occurring to their proteome when they are progressive destabilized by increasing the temperature. This SANS investigation is part of a more general study, where also the local and the global dynamics of the cellular proteome has been characterized in the temperature range where microbial life can thrive through measurements performed on the IN13 and IN5 spectrometers. We aim at providing a novel biophysical picture of the way the proteome dynamic and thermodynamic properties are linked to and possibly define the cellular thermal stability.
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PETERS Judith; DI BARI Daniele; Claudia Fasolato; GIUDICI ORTICONI Marie Therese; GUIRAL Marianne; MARTEL Anne; Alessandro Paciaroni; PORCAR Lionel and STERPONE Fabio. (2019). Proteome structural changes along the path toward bacterial death. A small angle neutron scattering study.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-983
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