Dynamics of phospholipid membranes altered by fragments of the Alzheimer’s disease peptide amyloid-beta
The peptide Amyloid-ß (Aß is the main constituent of senile plaques and is a pathological hallmark in Alzheimer’s disease. Recently, we have investigated how the fragment Aß(25-35) and Aß(22-40) influence the dynamics in phospholipid membranes [1,2]. Most important, we could demonstrate, that the insertion of Aß fragments into DMPC/DMPS membranes increases the lateral diffusion velocity, especially in the liquid-crystalline phase. This phase is the biologically most relevant one. The published results where obtained on the time-of-flight spectrometer NEAT with an energy-resolution 93 µeV. Here, we like to confirm and extend these results with a better energy-resolution of approx. 1 and 15 µeV.
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KARASTANEVA Hristina; BARRETT Matthew; DENCHER Norbert A.; Thomas Hauß; OLLIVIER Jacques and SEYDEL Tilo. (2012). Dynamics of phospholipid membranes altered by fragments of the Alzheimer’s disease peptide amyloid-beta. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-663
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