Dynamics of lipoprotein particles under high pressure
We propose to investigate molecular dynamics of native and biochemically modified low density lipoprotein (LDL) nanoparticles, which are macromolecular assemblies of phospholipids, cholesterol and fat stabilized by a protein moiety, under high hydrostatic pressure. The conception of a dynamic landscape similar to natural membranes seems to be reasonable for lipoprotein species, which we assume to be highly sensitive to pressure. Thus this project aims to study the impact of specific modifications of LDL on the dynamics, organization and interplay of lipids and protein under high pressure conditions. By combining all data we expect to obtain a more comprehensive picture of the structure and dynamics of LDL to be discussed in relation to its biological role.
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PRASSL Ruth; CARLBERG Miriam; CHOPLIN Arthur; MARION Jeremie and PETERS Judith. (2013). Dynamics of lipoprotein particles under high pressure. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-694
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