Dynamics studies on OPN 1-149, an intrinsically disordered peptide
Osteopontin (OPN) is an intrinsically disordered polypeptide, which sequesters amorphous calcium phosphate forming a type of calcium phosphate nanoclusters, under the correct conditions. These not only play essential regulatory biological roles but also present numerous potential applications, e.g. in the control of mineralisation of prostheses and implants, in the production of stable artificial biofluids or high calcium beverages and foods and in the new technologies of tissue engineering. We propose to compare by neutron scattering the respective thermal dynamics of free OPN (1-149) and of the nanoclusters. The data will provide important information on the relative flexibility and forces stabilizing the two structures.
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Teixeira; Bernhard Frick; HAERTLEIN Michael; HOLT Carl; LENTON Samuel; NYLANDER Tommy; OLLIVIER Jacques; SEYDEL Tilo and ZACCAI Joseph. (2013). Dynamics studies on OPN 1-149, an intrinsically disordered peptide. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-706
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