Protein relaxation dynamics as affected by biocompatible and biodegradable polymer solvation.
Protein-polymer conjugates combine the biological activities of proteins with the convenient handling and processability of synthetic polymers. The attachment of synthetic macromolecules to biological molecules has proven to be an efficient strategy to improve protein stability, reduce immunogenicity, developing of biomarkers and drug delivery complexes. Very little is known on the mechanisms leading to such effects, in particular structural and dynamics properties like changes in protein conformation/fluctuation or organization of the polymer shell around the protein. It has been lately demonstrated that the requirement of hydration water it is not necessary in order to enable protein fluctuation in the ps-ns time scales [3]. Hence the urgency to better understand the protein relaxation dynamics as affected by different biocompatible and biodegradable polymers and if a general behaviors apply.
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RUSSO Daniela; Simone Capaccioli; Bernhard Frick; PLAZANET Marie; SEYDEL Tilo; TEIXEIRA Jose; WEIK Martin and WURM Frederick. (2014). Protein relaxation dynamics as affected by biocompatible and biodegradable polymer solvation.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-718
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