Static versus dynamic protein clusters in solutions of bovine beta-lactoglobulin
The issue of the presence of dynamic or transient clusters in protein solutions is of great current interest due its relevance for understanding pathological pathways as well as for drug design [K.P.Johnston et al., ACS Nano Vol.6, p.1357 (2012)]. Earlier studies combining SAXS and neutron spin-echo spectroscopy have addressed this issue using the model protein lysozyme [L.Porcar et al., J. Phys. Chem. Lett. Vol.1, p.126 (2010)]. Here we propose a systematic study of transient or dynamic protein clusters in aqueous solutions to a new model protein beta-lactoglobulin. We propose to measure the diffusion function for several values of q below and above q_c, and, using neutron spin-echo (IN11) and the new spectrometer IN16B, measure the self-diffusion for several protein concentrations. In combination with the accumulated results of SAXS and DLS by our group on BLG and also other proteins, we expect to gain quantitative knowledge on BLG clusters.
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ZHANG Fajun; CZAKKEL Orsolya; FEUSTEL Michal; GRIMALDO Marco; JACOBS Robert; MATSARSKAIA Olga; ROOSEN RUNGE Felix; Frank Schreiber; SEYDEL Tilo and SOHMEN Benedikt. (2014). Static versus dynamic protein clusters in solutions of bovine beta-lactoglobulin. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-724
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