Probing dynamics of the hemoglobin confined inside silica tubes
Artificial matrices such as inorganic porous media are often employed to mimic a living cell. Unlike the in vivo environment inside a cell, artificial matrices can be suitably constructed to impart beneficial physical properties to confined biological molecules such as proteins. The vivid manifestation of biological molecules confined inside inorganic hosts can be observed in the fields of sensing, catalysis, sustained delivery. We have recently shown enhanced electrochemical response and structural stability of heme proteins confined inside various organic and inorganic hosts compared to the proteins in solution. The observed changes were attributed to the differences in protein configurations between unconfined and confined proteins. The protein configurations and dynamics are often correlated to the solvation dynamics. We would like to investigate the unconfined and confined protein dynamics using elastic and quasielastic neutron scattering using IN13 and IN5. Neutron scattering is the only effective characterizing tool to study the effect of the solvation on the protein dynamics.
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BHATTACHARYYA Aninda Jiban; GOPE Subhra; NATALI Francesca; OLLIVIER Jacques and SAMAJDAR Rudra Narayan. (2014). Probing dynamics of the hemoglobin confined inside silica tubes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-726
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