Beta-Lactoglobulin partial and kinetical unfolding process probed through dynamics under high pressure.
The protein folding/unfolding process represents today in science a deep open question. We thus decided to investigate the unfolding process of beta-lactoglobulin (LG) which involves different steps and did already preliminary studies under high pressure. Within the framework of the long term proposal LTP 8-4 (see ILL report LTP 8-4) we probed the protein on D16 and IN16 under high pressure and got interesting results with respect to the large scale structure and dynamics. Some of the involved processes take a rather long time to be fully achieved (several hours or days). This emerged through changes over time during measurements at a specific pressure and temperature. Indeed several competitive effects may participate to the unfolding mechanism as aggregation, partial unfolding and water insertion. We thus wish to further investigate the system to better understand the consecutive steps and their meaning.
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
MARION Jeremie; OLLIVIER Jacques and PETERS Judith. (2015). Beta-Lactoglobulin partial and kinetical unfolding process probed through dynamics under high pressure.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-737
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.